Effect of Food on Oral Absorption. Deflazacort: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Deflazacort. Management: Administer one third of the recommended deflazacort dose when used together with a strong or moderate CYP3A4 inhibitor. Both atazanavir and indinavir can increase the amount of bilirubin in your blood. Which drugs or supplements interact with indinavir? VinCRIStine Liposomal: CYP3A4 Inhibitors Strong may increase the serum concentration of VinCRIStine Liposomal.
Consider discontinuing indinavir in patients with severe leukocyturia. To help decrease the risk of while taking indinavir, drink at least 6 full glasses 8 ounces or 240 milliliters each of water or other liquids throughout the day. As your gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time soon after starting or many months later.
Warnke D, Barreto J, Temesgen Z "Antiretroviral drugs. Genentech USA. Invirase saquinavir mesylate capsules and tablets prescribing information. South San Francisco, CA; 2012 Feb. MorrisonGriffiths S, Newman M, OMahony C, Pirmohamed M "Adverse drug reaction of the month - Haemolytic anaemia associated with indinavir.
Telithromycin: CYP3A4 Inhibitors Strong may increase the serum concentration of Telithromycin. Canadian indication. When ulipristal is used as an emergency contraceptive, patients receiving this combo should be monitored for ulipristal toxicity. ONGLYZA or placebo. The 10 mg dosage is not an approved dosage. Median follow-up was 24 months. Single 40-mg oral dose.
There may be new information. Henderson DK. Postexposure prophylaxis for occupational exposures to hepatitis B, hepatitis C, and human immunodeficiency virus. Patients with renal or hepatic impairment should not be given colchicine with CRIXIVAN. Concomitant use with certain drugs not recommended or requires particular caution. 1 See Specific Drugs and Food under Interactions. Ceritinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ceritinib. Management: If such combinations cannot be avoided, the ceritinib dose should be reduced by approximately one-third to the nearest 150 mg. Resume the prior ceritinib dose after cessation of the strong CYP3A4 inhibitor. Take this medication by as directed by your doctor. Dosage is based on your medical condition, age, and response to treatment. Your dose may be gradually increased until the drug starts working well. Follow your doctor's instructions closely to reduce the risk of side effects. Both CRIXIVAN and atazanavir are associated with indirect unconjugated hyperbilirubinemia. Combinations of these drugs have not been studied and coadministration of CRIXIVAN and atazanavir is not recommended. Symptoms may include nausea; vaginal bleeding. Indinavir with or without low-dose ritonavir not recommended for initial treatment regimens in antiretroviral-naive pediatric patients because of high incidence of hematuria, sterile leukocyturia, and nephrolithiasis in children. Mellors JW, Rinaldo CR Jr, Gupta P et al. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. Some kidney stones are struvite stones.
Benperidol: CYP3A4 Inhibitors Strong may increase the serum concentration of Benperidol. Sildenafil: Protease Inhibitors may increase the serum concentration of Sildenafil. Sarilumab: May decrease the serum concentration of CYP3A4 Substrates. Csajka C, Marzolini C, Fattinger K, et al. "Population pharmacokinetics of indinavir in patients infected with human immunodeficiency virus. Tetrahydrocannabinol: CYP3A4 Inhibitors Strong may increase the serum concentration of Tetrahydrocannabinol. CRIXIVAN Capsules are sensitive to moisture. PredniSONE: CYP3A4 Inhibitors Strong may increase the serum concentration of PredniSONE. Carcinogenicity studies were conducted in mice and rats. In mice, no increased incidence of any tumor type was observed. Wasmuth JC, Lambertz I, Voigt E, et al. "Maintenance of indinavir by dose adjustment in HIV-1-infected patients with indinavir-related toxicity. New onset diabetes mellitus, exacerbation of pre-existing diabetes mellitus and hyperglycemia have been reported during post-marketing surveillance in HIV-infected patients receiving protease inhibitor therapy. Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. In some cases, diabetic ketoacidosis has occurred. In those patients who discontinued protease inhibitor therapy, hyperglycemia persisted in some cases. Because these events have been reported voluntarily during clinical practice, estimates of frequency cannot be made and a causal relationship between protease inhibitor therapy and these events has not been established. Patients with renal or hepatic impairment should not be given colchicine with Crixivan. If you take Crixivan with MYCOBUTIN, your doctor may adjust both the dose of MYCOBUTIN and the dose of Crixivan. Szczech LA "Hypertension and medication-related renal dysfunction in the HIV-infected patient. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. If your symptoms do not improve or if they become worse, check with your doctor. dapoxetine
Cigarette decreases levels of this medication. Indinavir-induced neuropathy may result in erectile dysfunction. Leukocyturia, crystalluria, and dysuria have been reported during postmarketing experience. Your doctor may want to change your medicine. Let your healthcare professionals know if your heart rate slows below 50 beats per minute or if you have any dizziness, fatigue, or other symptoms of low blood pressure such as fainting or lightheadedness. Let your doctor know if you experience a racing heart, chest pressure, or worsening shortness of breath. Lo JC, Mulligan K, Tai VW et al. “Buffalo hump” in men with HIV-1 infection. Lancet. L90M at which substitutions are associated with resistance, have been identified. Resistance was mediated by the co-expression of multiple and variable substitutions at these positions.
Lumpkin MM. Dear healthcare provider letter: Reports of diabetes and hyperglycemia in patients receiving protease inhibitors for the treatment of human immunodeficiency virus HIV. Take this medication by as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Swallow this medication whole with a glass of water. Do not crush or chew the tablets. Pranlukast: CYP3A4 Inhibitors Strong may increase the serum concentration of Pranlukast. Indinavir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control eg, condoms if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. ONGLYZA 5 mg group and 5 units for the placebo group. order now sominex online shop
Indinavir may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use indinavir with caution. Most are made of compounds, especially oxalate. phosphate and other minerals also may be present. Spontaneous bleeding noted with PIs; causal relationship not established. Rifabutin: Indinavir may increase serum concentrations of the active metabolites of Rifabutin. Rifabutin may decrease the serum concentration of Indinavir. Indinavir may increase the serum concentration of Rifabutin. Management: Reduce rifabutin dose by 50% and increase adult indinavir dose to 1 g every 8 hours, per US labeling. Continue to take indinavir even if you feel well. Do not miss any doses. Ribociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ribociclib. Management: Avoid use of ribociclib with strong CYP3A4 inhibitors when possible; if combined use cannot be avoided, reduce ribociclib dose to 400 mg once daily. Grases F, Garcia-Gonzalez R, Redondo E, et al. "Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. Treatment of more severe episodes of PCP with MEPRON has not been studied. Etoposide: Atovaquone may increase the serum concentration of Etoposide. Management: Consider separating the administration of atovaquone and etoposide by at least 1 to 2 days. Children may be more sensitive to the side effects of this drug, especially effects on the kidney such as kidney stones. Always have another kind of birth control eg, condoms to use as a backup in case you miss pills. Also, always have an extra, full pack of pills. AUC values in subjects with normal renal function. Cohen Stuart JWT, Schuurman R, Burger DM et al. Randomized trial comparing saquinavir soft gelatin capsules versus indinavir as part of triple therapy CHEESE study. AIDS. AIDS or other sexually transmitted diseases. Also, it will not keep you from giving HIV to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has HIV. Do not share needles with anyone.
Crixivan Capsules are sensitive to moisture. Crixivan should be dispensed and stored in the original container. The desiccant should remain in the original bottle. Do not share needles or other injection equipment. High levels of also increase the risk for calcium stones. MiFEPRIStone: CYP3A4 Inhibitors Strong may increase the serum concentration of MiFEPRIStone. Bristol-Myers Squibb. Videx didanosine prescribing information. Princeton, NJ; 2009 Jun. Tamsulosin: CYP3A4 Inhibitors Strong may increase the serum concentration of Tamsulosin. Caucasian 75% with a mean age of 65 years. Do not stop taking any medications without consulting your healthcare provider. Registered trademark of Pfizer, Inc. Registered trademark of Eli Lilly and Company. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. II evaluation of the HIV protease inhibitor MK-639 indinavir. AIDS. generic perindopril order mastercard europe
Experts state indinavir without low-dose ritonavir not recommended at any time in pregnant women. 202 Substantially decreased plasma indinavir concentrations reported during pregnancy. 1 202 See Absorption: Special Populations under Pharmacokinetics. Patients with hemophilia: There have been reports of spontaneous bleeding in patients with hemophilia A and B treated with protease inhibitors. In some patients, additional factor VIII was required. In many of the reported cases, treatment with protease inhibitors was continued or restarted. A causal relationship between protease inhibitor therapy and these episodes has not been established. Have your and checked regularly while taking this medication. Discuss with your doctor how to monitor your own pressure and pulse. Merrill DP, Moonis M, Chou TC et al. Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro. J Infect Dis. Proton Pump Inhibitors: May decrease the serum concentration of Indinavir. Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. What should I avoid while taking ZERIT?
Naloxegol: CYP3A4 Inhibitors Strong may increase the serum concentration of Naloxegol. Hypersensitivity side effects have included anaphylactoid reactions, urticaria, and vasculitis during postmarketing experience. Miller KD, Jones E, Yanovski JA et al. Visceral abdominal-fat accumulation associated with use of indinavir. Lancet. What should I avoid while taking alosetron Lotronex? It is not known whether Crixivan is dialyzable by peritoneal or hemodialysis. Calcifediol: CYP3A4 Inhibitors Strong may increase the serum concentration of Calcifediol. Delavirdine: Protease Inhibitors may decrease the serum concentration of Delavirdine. Delavirdine may increase the serum concentration of Protease Inhibitors. Kopp JB, Miller KD, Mican JM et al. Crystalluria and urinary tract abnormalities associated with indinavir. Ann Intern Med. St. John's wort is not recommended. persantine
CYP3A4 inhibitor. Monitor for increased mifepristone toxicity regardless of dose or indication. Impact of Antiretroviral Therapy. Manfredi R, Calza L, Chiodo F "Gynecomastia associated with highly antiretroviral therapy. You are breastfeeding. Do not breastfeed. We do not know if Crixivan can be passed to your baby in your breast milk and whether it could harm your baby. Also, mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk. ZERIT will not cure your HIV infection. Delavirdine: Delavirdine inhibits the metabolism of indinavir such that coadministration of 400-mg or 600-mg indinavir three times daily with 400-mg delavirdine three times daily alters indinavir AUC, C max and C min see . Indinavir had no effect on delavirdine pharmacokinetics see based on a comparison to historical delavirdine pharmacokinetic data. ZERIT is used alone. Squibb Pharmaceuticals January 8, 2004. Temsirolimus. Levels of sirolimus, the active metabolite, may be increased, likely due to inhibition of CYP-mediated metabolism. Pain or sores in the and throat may occur. Everolimus can commonly cause a mild that is usually not serious. Rinse your frequently with cool water mixed with or salt. It may also be best to eat soft, moist foods. Mild to moderate hepatic impairment due to cirrhosis: 600 mg every 8 hours. Stop taking alosetron and call your doctor if you become constipated while taking alosetron.
Cyclophosphamide. Specifically, the incidences of neutropenia, infection, and mucositis may be increased. ZERIT belongs to a class of drugs called nucleoside analogues. ZERIT may be taken with or without food. Simvastatin: CYP3A4 Inhibitors Strong may increase the serum concentration of Simvastatin. Garlic: May decrease the serum concentration of Protease Inhibitors. Management: Concurrent use of garlic supplements with protease inhibitors is not recommended. order cheapest azathioprine canada
Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Acquir Immune Defic Syndr. Zopiclone: CYP3A4 Inhibitors Strong may increase the serum concentration of Zopiclone. Bosutinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Bosutinib. DOXOrubicin Conventional: CYP3A4 Inhibitors Strong may increase the serum concentration of DOXOrubicin Conventional. Management: Seek alternatives to strong CYP3A4 inhibitors in patients treated with doxorubicin whenever possible. Additionally, monitor for possible reduced response to indinavir. Condra JH, Holder DJ, Schleif WA et al. Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol. Procoralan ivabradine hydrochloride summary of product characteristics. Les Laboratoires Servier March, 2015. MEPRON suspension or aerosolized pentamidine.
Saez-Llorens X, Ramilo O. Early experience with protease inhibitors in human immunodeficiency virus-infected children. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Product Information. Crixivan indinavir. Panel on Antiretroviral Guidelines for Adults and Adolescents, US Department of Health and Human Services HHS. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents May 1, 2014. Updates may be available at HHS AIDS Information AIDSinfo website. Roling J, Schmid H, Fischereder M, Draenert R, Goebel FD "HIV-Associated Renal Diseases and Highly Active Antiretroviral Therapy-Induced Nephropathy. Sildenafil dose should not exceed a maximum of 25 mg in a 48-hour period in patients receiving concomitant CRIXIVAN therapy. Use with increased monitoring for adverse events. Gastrointestinal disorders: Consider parenteral therapy with alternative agents in patients who have difficulty taking atovaquone with food. Gastrointestinal disorders may limit absorption of oral medications; may not achieve adequate plasma levels. There are no adequate and well-controlled studies in pregnant patients. Crixivan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Dasatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Dasatinib. Management: Use of this combination should be avoided; consider reducing dasatinib dose if a strong CYP3A4 inhibitor must be used. emis.info nolvadex
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You could get pregnant if you have sex in the 7 days after you miss pills. Zolpidem: CYP3A4 Inhibitors Strong may increase the serum concentration of Zolpidem. Crystalluria and nephrolithiasis may occur during treatment with indinavir. The cumulative frequency of nephrolithiasis is substantially higher in pediatric patients 29% than in adult patients 12. Contact your doctor if you miss any menstrual periods so that the cause may be determined.
Reyataz atazanavir sulfate US prescribing information. Levomilnacipran: CYP3A4 Inhibitors Strong may increase the serum concentration of Levomilnacipran. TraMADol: CYP3A4 Inhibitors Strong may increase the serum concentration of TraMADol.
Sherman KE. Mechanism of indinavir-induced hyperbilirubinemia. Dose reduction of Crixivan to 600 mg every 8 hours is recommended when administering itraconazole concurrently. Using indinavir with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Agenerase amprenavir Capsules US prescribing information. GlaxoSmithKline May, 2005.
Imidafenacin: CYP3A4 Inhibitors Strong may increase the serum concentration of Imidafenacin. Simeprevir: CYP3A4 Inhibitors Strong may increase the serum concentration of Simeprevir. For patent information: www.